Increasing antibiotic resistance of bacteria is one of the biggest future challenges of medicine. Nature may offer us new solutions in the form of oligomeric ellagitannins. A joint project of HUS Helsinki University Hospital, VTT Technical Research Centre of Finland, University of Turku, and Hospital Universitario Principe de Astúrias and research institute Fundación Jiménez Díaz […]
The XXX International Conference on Polyphenols was successfully organized 13-15 July 2021 in Turku. Natural Chemistry Research Group was responsible for the organization of the anniversary XXX International Conference on Polyphenols. It was held as a fully virtual conference, and it was a huge success. We had three days fully packed with tens of scientific […]
The partition coefficients between n-octanol and water of 47 hydrolysable tannins were measured utilizing UPLC and HPLC with UV detection. Recently, we studied the hydrophobicity of hydrolysable tannins with a large set of hydrolysable tannins in order to reveal and understand the structural features affecting their hydrophobicity that would help in estimating the biological activity […]
The growth inhibition effect of 22 individual ellagitannins and of pentagalloylglucose was tested on four bacterial species: Clostridiales perfringens, Escherichia coli, Lactobacillus plantarum and Staphylococcus aureus Recently, we published a paper looking at the antimicrobial activities of ellagitannins and found ellagitannins to be potent and promising antimicrobials: Puljula E, Walton G, Woodward MJ, Karonen M. […]
The effects of structurally unique ellagitannins on the exsheathment of third-stage infective larvae were examined on H. contortus and T. colubriformis by the in vitro larval exsheathment inhibition assay Recently, we studied the anthelmintic effects of 30 individual ellagitannins to find out how a structurally diverse array of ellagitannins differs at inhibiting the third-stage infective […]
Ellagitannins with glucopyranose cores have higher affinities to proteins than acyclic ellagitannins by isothermal titration calorimetry Recently, we published a paper looking at the ellagitannin-protein interactions and their thermodynamics by isothermal titration calorimetry (ITC): Karonen M, Oraviita M, Mueller-Harvey I, Salminen J-P, Green Rebecca J. 2019. Ellagitannins with glucopyranose cores have higher affinities to proteins […]
Structural features of hydrolysable tannins reveal their capacity to precipitate a model protein Our long term efforts at the Natural Chemistry Research Group regarding structure-activity studies of hydrolysable tannins (HTs) have resulted in a new scientific paper by Engström et al. (2019) reporting the ability of 32 purified and characterized HTs to form insoluble complexes with […]
The best NCRG paper of 2018: Leppä et al. Journal of Chromatography A 1576:67–79. We at the Natural Chemistry Research Group had an internal vote for our best paper published in 2018. Milla’s paper reporting the developments in the chromatographic purification of proanthocyanidins came out as a clear winner. Congrats Milla! This was actually a perfect […]
Advances in Polyphenol Research: A Journal of Agricultural and Food Chemistry Virtual Issue Scientists have investigated polyphenols since at least the start of the 19th century, and these compounds continue to be the subject of intense activity, with some 500 papers published in just the Journal of Agricultural and Food Chemistry (JAFC) between January 2016 and July […]
Positions are now open in our Master’s Degree Programme, where you can choose between three disciplines belonging to the field of Medicinal and Radiopharmaceutical Chemistry Our programme provides you with strong knowledge on one or more of the following topics: design and synthesis of new drugs, radiolabelling and enhanced targeting of drugs, or screening, isolation […]